As Diablo 4 enters its fiery new chapter with Season 10: Season of Infernal Chaos, Sanctuary's bravest adventurers are diving into the revamped endgame boss system — and for good reason. Blizzard's latest overhaul introduces fresh loot tables, higher Mythic drop chances, and newly structured boss-specific loot pools that make farming your dream gear more efficient than ever. Whether you're hunting for class-defining Uniques or the rarest Mythic treasures, understanding each boss's loot table is essential to Diablo 4 Items mastering the Season of Infernal Chaos.

The Season of Infernal Chaos – Overview

Season 10 expands upon the Vessel of Hatred foundation with a greater emphasis on targeted loot farming. Each endgame boss now has a more distinct drop pool, giving players a clearer path to specific Uniques and Mythics. Furthermore, Blizzard has removed the old “invulnerability phase” mechanic that frustrated high-DPS players, replacing it with a shield barrier system that encourages faster and more fluid fights.

The other big news is the introduction of Infernal Echoes, a new crafting material that increases your odds of Mythic and Uber Unique drops when used in boss summon rituals. Combined with new boss-specific reagents, the endgame grind now feels both rewarding and strategic.

Major Boss Loot Tables

Below is a breakdown of the key endgame bosses in Season 10, their summoning requirements, and their most notable loot drops.

1. Grigoire, The Famine Feast

Summon Requirement: 12 Living Steel

Recommended Level: World Tier 4

Grigoire's loot table is among the most diverse in Season 10. As a lightning-imbued demon who feeds off chaos energy, he now drops several new Uniques across all classes.

Barbarian: Rage of Harrogath, Overkill, Ancient's Oath

Druid: Hunter's Zenith, Mad Wolf's Glee

Sorcerer: Raiment of the Infinite, Esu's Heirloom

Rogue: Word of Hakan, Skyhunter

Necromancer: Bloodless Scream, Deathless Visage

Grigoire is an excellent starting point for players climbing into higher Torment tiers, as his loot pool contains many “build-defining” Uniques that boost core class synergies.

2. Lord Zir, the Blood Knight

Summon Requirement: 12 Exquisite Blood

Lord Zir remains one of the most rewarding bosses for advanced players due to his dual-phase fight and high Mythic drop potential. His loot focuses heavily on physical and bleed mechanics.

Barbarian: Ramaladni's Magnum Opus, Hellhammer

Rogue: Windforce, Eaglehorn

Druid: Vasily's Prayer, Insatiable Fury

Necromancer: Howl from Below, Ring of Mendeln

Sorcerer: Flickerstep, Starfall Coronet

Zir's fight is intense but worth the effort — his hoard has an increased chance of dropping Uber Uniques compared to standard endgame bosses.

3. The Beast in the Ice

Summon Requirement: 12 Distilled Fear

This chilling nightmare returns in Season 10 with a reworked loot table that favors resistance-heavy and hybrid builds. The Beast in the Ice is an ideal target for players seeking tank or shapeshifting Uniques.

Druid: Kilt of the Blackwing, Storm's Companion

Barbarian: Ancient's Oath, Fields of Crimson

Sorcerer: Esadora's Overflowing Cameo, Staff of Lam Esen

All Classes: Chance at Godslayer Crown and Frostburn

Because of his unique elemental damage type, farming this boss is a good test of your build's resilience while rewarding you with versatile class items.

4. Duriel, King of Maggots

Summon Requirement: 3 Shards of Agony (from Grigoire or Varshan)

Duriel is widely considered the best boss for Mythic farming this season. He retains a double drop rate for Mythic Uniques compared to others and has one of the richest loot tables in Diablo 4 history.

All Classes: Andariel's Visage, Harlequin Crest (Shako), Doombringer, Azurewrath, The Grandfather

Seasonal Mythic Drops: Soulbrand, Crown of the Abyss

If you're aiming for the rarest loot in the game, Duriel is your go-to. However, his poison and corrosion mechanics are more lethal this season — bring antidotes and strong sustain builds.

5. Andariel, Maiden of Anguish

Summon Requirement: 3 Pincushioned Dolls

Andariel makes her full return in Season 10, complete with a new Infernal Chaos variant. She's a fast, venomous opponent whose loot table skews toward agility and damage-over-time items.

Rogue: Eyes in the Dark, Condemnation

Sorcerer: Raiment of the Infinite, Gloves of the Illuminated Veil (Season 10 exclusive)

All Classes: Flickerstep, X'Fal's Corroded Signet

Andariel's hoard has a small chance to include Infernal Echoes — making her an excellent target for Mythic pre-farming before you tackle Duriel or Belial.

6. Belial, Lord of Lies

Summon Requirement: 3 Infernal Mirrors

Belial headlines Season 10 as the ultimate boss encounter. His fight rewards precision and adaptability, but the payoff is immense. Belial's hoard lets players choose another boss's loot pool, offering unprecedented flexibility.

Mythic Drop Chance: Highest in the game

Exclusive Loot: Chaos Sigil, Ring of False Promises, Veil of Damnation

Special Feature: Selecting a boss-specific loot pool when claiming rewards

For min-maxers, Belial is the pinnacle of loot optimization. A single kill can yield multiple top-tier Uniques or Mythics if you use Infernal Echoes effectively.

Farming Tips for Season 10

Focus on Boss Rotations: Many players overlook efficient rotations. Run Grigoire → Zir → Beast → Duriel for the best chance at diverse loot pools.

Stack Infernal Echoes: Using them during summons dramatically boosts Mythic chances. Save them for Duriel or Belial.

Master the Shield Phase: With invulnerability gone, damage during shield phases now matters more than ever — optimize burst windows.

Use Belial Wisely: If RNG hasn't blessed you with your desired Unique, use Belial's hoard to target that specific boss's loot pool.

Play in Groups: Loot share among party members makes farming faster — especially for high-demand Mythics.

 Final Thoughts

Season 10: Season of Infernal Chaos transforms buy Diablo 4 Items endgame into a refined, strategy-driven experience. The redesigned boss loot tables give purpose to every fight, letting you focus your farming instead of relying on pure luck. From Grigoire's broad loot pool to Belial's customizable hoard, every encounter feels meaningful.

Whether you're chasing a class-defining Unique or that elusive Mythic crown, mastery of these boss loot tables will be the key to dominating Season 10. Gather your Infernal Echoes, summon your targets, and dive into the chaos — Sanctuary's richest treasures await those bold enough to claim them.